Development, differentiation, and proliferation of macrophages in the rat yolk sac

K Takahashi, M Naito - Tissue and Cell, 1993 - Elsevier
Immunohistochemical and immunoelectron microscopic investigation using anti-rat
macrophage monoclonal antibody (mAb) RM-1 demonstrated the first emergence of
immature macrophages within blood islands of fetal rat yolk sacs at fetal day 9. At fetal day
10, they matured into fetal macrophages, showed intense immunoreactivity to RM-1,
developed lysosomal granules, endocytic vesicles or vacuoles, and extended fine
cytoplasmic processes By the rosetting assay with IgG-coated sheep erythrocyte antibody …