[HTML][HTML] The angiotensin II AT2 receptor is an AT1receptor antagonist
S AbdAlla, H Lother, AM Abdel-tawab… - Journal of Biological …, 2001 - ASBMB
The vasopressor angiotensin II activates AT 1 and AT 2 receptors. Most of the knownin vivo
effects of angiotensin II are mediated by AT 1 receptors while the biological functions of AT 2
receptors are less clear. We report here that the AT 2 receptor binds directly to the AT 1
receptor and thereby antagonizes the function of the AT 1 receptor. The AT 1-specific
antagonism of the AT 2 receptor was independent of AT 2 receptor activation and signaling,
and it was effective on different cells and on human myometrial biopsies with AT 1/AT 2 …
effects of angiotensin II are mediated by AT 1 receptors while the biological functions of AT 2
receptors are less clear. We report here that the AT 2 receptor binds directly to the AT 1
receptor and thereby antagonizes the function of the AT 1 receptor. The AT 1-specific
antagonism of the AT 2 receptor was independent of AT 2 receptor activation and signaling,
and it was effective on different cells and on human myometrial biopsies with AT 1/AT 2 …