[HTML][HTML] The WD repeat: a common architecture for diverse functions
TF Smith, C Gaitatzes, K Saxena, EJ Neer - Trends in biochemical sciences, 1999 - cell.com
TF Smith, C Gaitatzes, K Saxena, EJ Neer
Trends in biochemical sciences, 1999•cell.comOur knowledge of the large family of proteins that contain the WD repeat continues to
accumulate. The WD-repeat proteins are found in all eukaryotes and are implicated in a
wide variety of crucial functions. The solution of the three-dimensional structure of one WD-
repeat protein and the assumption that the structure will be common to all members of this
family has allowed subfamilies of WD-repeat proteins to be defined on the basis of probable
surface similarity. Proteins that have very similar surfaces are likely to have common binding …
accumulate. The WD-repeat proteins are found in all eukaryotes and are implicated in a
wide variety of crucial functions. The solution of the three-dimensional structure of one WD-
repeat protein and the assumption that the structure will be common to all members of this
family has allowed subfamilies of WD-repeat proteins to be defined on the basis of probable
surface similarity. Proteins that have very similar surfaces are likely to have common binding …
Abstract
Our knowledge of the large family of proteins that contain the WD repeat continues to accumulate. The WD-repeat proteins are found in all eukaryotes and are implicated in a wide variety of crucial functions. The solution of the three-dimensional structure of one WD-repeat protein and the assumption that the structure will be common to all members of this family has allowed subfamilies of WD-repeat proteins to be defined on the basis of probable surface similarity. Proteins that have very similar surfaces are likely to have common binding partners and similar functions.
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