Ontogeny of GnRH and olfactory neuronal systems in man: novel insights from the investigation of inherited forms of Kallmann's syndrome
D González-Martínez, Y Hu, PM Bouloux - Frontiers in neuroendocrinology, 2004 - Elsevier
GnRH embryonic neuronal fate is determined by discreet spatio-temporal expression
patterns and interactions of axonal guidance and cell adhesion molecules and extracellular
matrix proteins. Expression of several transcription factors, locally derived growth factors and
neurotransmitters influence GnRH ontogeny and rostral forebrain specification. In man,
disrupted GnRH neuronal ontogeny can be caused by several monogenic disorders leading
to isolated hypogonadotrophic hypogonadism (IHH); these include mutations within KAL-1 …
patterns and interactions of axonal guidance and cell adhesion molecules and extracellular
matrix proteins. Expression of several transcription factors, locally derived growth factors and
neurotransmitters influence GnRH ontogeny and rostral forebrain specification. In man,
disrupted GnRH neuronal ontogeny can be caused by several monogenic disorders leading
to isolated hypogonadotrophic hypogonadism (IHH); these include mutations within KAL-1 …