[HTML][HTML] Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial …
AD Watson, N Leitinger, M Navab, KF Faull… - Journal of Biological …, 1997 - ASBMB
Entry of monocytes into the vessel wall is an important event in atherogenesis. Previous
studies from our laboratory suggest that oxidized arachidonic acid-containing phospholipids
present in mildly oxidized low density lipoproteins (MM-LDL) can activate endothelial cells to
bind monocytes. In this study, biologically active oxidized arachidonic acid-containing
phospholipids were produced by autoxidation of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-
phosphocholine (Ox-PAPC) and analyzed by liquid chromatography and electrospray …
studies from our laboratory suggest that oxidized arachidonic acid-containing phospholipids
present in mildly oxidized low density lipoproteins (MM-LDL) can activate endothelial cells to
bind monocytes. In this study, biologically active oxidized arachidonic acid-containing
phospholipids were produced by autoxidation of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-
phosphocholine (Ox-PAPC) and analyzed by liquid chromatography and electrospray …