[HTML][HTML] Correlation of antiphospholipid antibody recognition with the structure of synthetic oxidized phospholipids: importance of Schiff base formation and Aldol …
P Friedman, S Hörkkö, D Steinberg… - Journal of Biological …, 2002 - ASBMB
The oxidation of low density lipoproteins (LDL) has been correlated with atherogenesis
through a variety of pathways. The process involves nonspecific fragmentation, oxidative
breakdown, and modification of the lipids and protein of LDL. The process yields a variety of
bioactive products, including aldehyde-containing phospholipids, which can cross-react with
primary amines (ie peptides or phospholipid head groups) to yield Schiff base products. We
also demonstrate that such oxidized phospholipid products may further react through a post …
through a variety of pathways. The process involves nonspecific fragmentation, oxidative
breakdown, and modification of the lipids and protein of LDL. The process yields a variety of
bioactive products, including aldehyde-containing phospholipids, which can cross-react with
primary amines (ie peptides or phospholipid head groups) to yield Schiff base products. We
also demonstrate that such oxidized phospholipid products may further react through a post …