[HTML][HTML] Cysteine-scanning mutagenesis of transmembrane segment 7 of the GLUT1 glucose transporter
PW Hruz, MM Mueckler - Journal of Biological Chemistry, 1999 - ASBMB
The human erythrocyte facilitative glucose transporter (Glut1) is predicted to contain 12
transmembrane spanning α-helices based upon hydropathy plot analysis of the primary
sequence. Five of these helices (3, 5, 7, 8, and 11) are capable of forming amphipathic
structures. A model of GLUT1 tertiary structure has therefore been proposed in which the
hydrophilic faces of several amphipathic helices are arranged to form a central aqueous
channel through which glucose traverses the hydrophobic lipid bilayer. In order to test this …
transmembrane spanning α-helices based upon hydropathy plot analysis of the primary
sequence. Five of these helices (3, 5, 7, 8, and 11) are capable of forming amphipathic
structures. A model of GLUT1 tertiary structure has therefore been proposed in which the
hydrophilic faces of several amphipathic helices are arranged to form a central aqueous
channel through which glucose traverses the hydrophobic lipid bilayer. In order to test this …