Helicobacter pylori infection and age on the development of intestinal metaplasia--a multiple logistic regression analysis.
CC Wang, MS Wu, HH Wang, HP Wang… - Hepato …, 1998 - europepmc.org
CC Wang, MS Wu, HH Wang, HP Wang, WC Lee, CT Shun, JT Lin
Hepato-gastroenterology, 1998•europepmc.orgResults Eighty-four patients (27.8%) had IM, while 185 patients (61.3%) were seropositive to
H. pylori. The frequency of IM was higher in patients with gastric ulcer (9/14, 64.3%) than in
those with minimal change (68/229, 29.7%) or duodenal ulcer (7/59, 11.9%), both p< 0.01.
Patients with IM had a higher mean age (49.5+/-14.1 vs. 42.3+/-9.0, p< 0.01) and a higher H.
pylori prevalence than those without IM (61/84, 72.6% vs. 124/218, 56.9%, p< 0.01). The
concordance rate of H. pylori infection between histopathologic and serologic diagnosis was …
H. pylori. The frequency of IM was higher in patients with gastric ulcer (9/14, 64.3%) than in
those with minimal change (68/229, 29.7%) or duodenal ulcer (7/59, 11.9%), both p< 0.01.
Patients with IM had a higher mean age (49.5+/-14.1 vs. 42.3+/-9.0, p< 0.01) and a higher H.
pylori prevalence than those without IM (61/84, 72.6% vs. 124/218, 56.9%, p< 0.01). The
concordance rate of H. pylori infection between histopathologic and serologic diagnosis was …
Results
Eighty-four patients (27.8%) had IM, while 185 patients (61.3%) were seropositive to H. pylori. The frequency of IM was higher in patients with gastric ulcer (9/14, 64.3%) than in those with minimal change (68/229, 29.7%) or duodenal ulcer (7/59, 11.9%), both p< 0.01. Patients with IM had a higher mean age (49.5+/-14.1 vs. 42.3+/-9.0, p< 0.01) and a higher H. pylori prevalence than those without IM (61/84, 72.6% vs. 124/218, 56.9%, p< 0.01). The concordance rate of H. pylori infection between histopathologic and serologic diagnosis was lower in patients with IM (67/84, 79.8%) than those without (196/218, 89.9%, p< 0.05). Using logistic regression analyses, the development of IM was noted to be independently related to both H. pylori infection (odds ratio= 1.97, 95% confidence interval: 1.1 (3.53)) and age (odds ratio= 1.93, 95% confidence interval: 1.51 (2.47)).
Conclusions
These data suggest that age and H. pylori infection are independent risk factors for the development of IM. Furthermore, H. pylori infection may have been underestimated in patients with IM because of the use of a single method of detection.
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