[HTML][HTML] The sialic acid component of the β1 subunit modulates voltage-gated sodium channel function
D Johnson, ML Montpetit, PJ Stocker… - Journal of Biological …, 2004 - ASBMB
Voltage-gated sodium channels (Na v) are responsible for initiation and propagation of
nerve, skeletal muscle, and cardiac action potentials. Na v are composed of a pore-forming
α subunit and often one to several modulating β subunits. Previous work showed that
terminal sialic acid residues attached to α subunits affect channel gating. Here we show that
the fully sialylated β 1 subunit induces a uniform, hyperpolarizing shift in steady state and
kinetic gating of the cardiac and two neuronal α subunit isoforms. Under conditions of …
nerve, skeletal muscle, and cardiac action potentials. Na v are composed of a pore-forming
α subunit and often one to several modulating β subunits. Previous work showed that
terminal sialic acid residues attached to α subunits affect channel gating. Here we show that
the fully sialylated β 1 subunit induces a uniform, hyperpolarizing shift in steady state and
kinetic gating of the cardiac and two neuronal α subunit isoforms. Under conditions of …
