[HTML][HTML] Evidence that receptor activator of nuclear factor (NF)-κB ligand can suppress cell proliferation and induce apoptosis through activation of a NF-κB …
AC Bharti, Y Takada, S Shishodia… - Journal of Biological …, 2004 - ASBMB
The receptor activator of NF-κB ligand (RANKL), a recently identified member of the tumor
necrosis factor (TNF) superfamily, has been shown to induce osteoclastogenesis and
dendritic cell survival. Most members of the TNF superfamily suppress cell proliferation and
induce apoptosis, but whether RANKL does so is not known. We demonstrate that treatment
of monocyte RAW 264.7 cells with RANKL induces dose-dependent growth inhibition (IC
50= 10 ng/ml) as determined by dye uptake and [3 H] thymidine incorporation methods …
necrosis factor (TNF) superfamily, has been shown to induce osteoclastogenesis and
dendritic cell survival. Most members of the TNF superfamily suppress cell proliferation and
induce apoptosis, but whether RANKL does so is not known. We demonstrate that treatment
of monocyte RAW 264.7 cells with RANKL induces dose-dependent growth inhibition (IC
50= 10 ng/ml) as determined by dye uptake and [3 H] thymidine incorporation methods …