[HTML][HTML] A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain
PC Reid, N Sakashita, S Sugii, Y Ohno-Iwashita… - Journal of lipid …, 2004 - ASBMB
Niemann-Pick type C (NPC) is a neurodegenerative disorder characterized by progressive
accumulation of cholesterol, gangliosides, and other lipids in the central nervous system and
visceral organs. In the NPC1 mouse model, neurodegeneration and neuronal cell loss occur
before postnatal day 21. Whether neuronal cholesterol accumulation occurs in vivo before
the first signs of neuronal cell loss has not been demonstrated. In this report, we used the
NPC1 mouse model and employed a novel cholesterol binding reagent, BCθ, that enabled …
accumulation of cholesterol, gangliosides, and other lipids in the central nervous system and
visceral organs. In the NPC1 mouse model, neurodegeneration and neuronal cell loss occur
before postnatal day 21. Whether neuronal cholesterol accumulation occurs in vivo before
the first signs of neuronal cell loss has not been demonstrated. In this report, we used the
NPC1 mouse model and employed a novel cholesterol binding reagent, BCθ, that enabled …