[HTML][HTML] Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: evidence that most of this steroid in the circulation is of pulmonary …
A Babiker, O Andersson, D Lindblom… - Journal of lipid …, 1999 - ASBMB
Human alveolar macrophages have exceptionally high capacity to convert cholesterol into
27-hydroxycholesterol and cholestenoic acid by the sterol 27-hydroxylase mechanism. It is
shown here that the human lung has a higher content of 27-hydroxycholesterol relative to
cholesterol than any other organ. In order to evaluate the importance of the sterol 27-
hydroxylase mechanism for cholesterol homeostasis in the lung, the production of
cholestenoic acid by human lung was investigated. Removal of one lung reduced the level …
27-hydroxycholesterol and cholestenoic acid by the sterol 27-hydroxylase mechanism. It is
shown here that the human lung has a higher content of 27-hydroxycholesterol relative to
cholesterol than any other organ. In order to evaluate the importance of the sterol 27-
hydroxylase mechanism for cholesterol homeostasis in the lung, the production of
cholestenoic acid by human lung was investigated. Removal of one lung reduced the level …