Pseudomonas aeruginosa Pyocyanin Is Critical for Lung Infection in Mice
GW Lau, H Ran, F Kong, DJ Hassett… - Infection and …, 2004 - Am Soc Microbiol
Infection and immunity, 2004•Am Soc Microbiol
Pseudomonas aeruginosa secretes copious amounts of the redox-active phenazine,
pyocyanin (PCN), during cystic fibrosis lung infection. PCN has been shown to interfere with
a variety of cellular processes in cultured lung epithelial cells. Here, by using two respiratory
tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis
during lung infection.
pyocyanin (PCN), during cystic fibrosis lung infection. PCN has been shown to interfere with
a variety of cellular processes in cultured lung epithelial cells. Here, by using two respiratory
tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis
during lung infection.
Abstract
Pseudomonas aeruginosa secretes copious amounts of the redox-active phenazine, pyocyanin (PCN), during cystic fibrosis lung infection. PCN has been shown to interfere with a variety of cellular processes in cultured lung epithelial cells. Here, by using two respiratory tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis during lung infection.
American Society for Microbiology