Negative Control of Flagellum Synthesis in Pseudomonas aeruginosa Is Modulated by the Alternative Sigma Factor AlgT (AlgU)
ES Garrett, D Perlegas, DJ Wozniak - Journal of bacteriology, 1999 - Am Soc Microbiol
ES Garrett, D Perlegas, DJ Wozniak
Journal of bacteriology, 1999•Am Soc MicrobiolMany respiratory isolates of Pseudomonas aeruginosa from cystic fibrosis patients are
mucoid (alginate producing) yet lack flagella. It was hypothesized that an alginate regulator
inhibits flagellar gene expression. Mutations in algB, algR, and algT resulted in nonmucoid
derivatives, yet algT mutants expressed flagella. AlgT-dependent control of flagellum
synthesis occurred through inhibition of fliC but not rpoN transcription.
mucoid (alginate producing) yet lack flagella. It was hypothesized that an alginate regulator
inhibits flagellar gene expression. Mutations in algB, algR, and algT resulted in nonmucoid
derivatives, yet algT mutants expressed flagella. AlgT-dependent control of flagellum
synthesis occurred through inhibition of fliC but not rpoN transcription.
Abstract
Many respiratory isolates of Pseudomonas aeruginosafrom cystic fibrosis patients are mucoid (alginate producing) yet lack flagella. It was hypothesized that an alginate regulator inhibits flagellar gene expression. Mutations in algB,algR, and algT resulted in nonmucoid derivatives, yet algT mutants expressed flagella. AlgT-dependent control of flagellum synthesis occurred through inhibition of fliC but not rpoN transcription.
American Society for Microbiology