[HTML][HTML] Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck
P Lock, F Casagranda, AR Dunn - Journal of Biological Chemistry, 1999 - ASBMB
A murine embryonic cDNA library was screened for potential substrates of the Src family
kinase, Lyn, using a phosphorylation-screening strategy. One cDNA that we identified
encodes Dok-related protein (DokR), a protein with homology to p62 dok (Dok), and
members of the insulin receptor substrate-1 family of proteins. Analysis of murine tissue
extracts with DokR-specific antisera revealed that DokR protein is expressed at highest
levels in lymphoid tissues. Co-expression of a FLAG epitope-tagged form of DokR (FLAG …
kinase, Lyn, using a phosphorylation-screening strategy. One cDNA that we identified
encodes Dok-related protein (DokR), a protein with homology to p62 dok (Dok), and
members of the insulin receptor substrate-1 family of proteins. Analysis of murine tissue
extracts with DokR-specific antisera revealed that DokR protein is expressed at highest
levels in lymphoid tissues. Co-expression of a FLAG epitope-tagged form of DokR (FLAG …
