[HTML][HTML] Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-κB activation
O Gutierrez, C Pipaon, N Inohara, A Fontalba… - Journal of Biological …, 2002 - ASBMB
Nod2, a member of the Apaf1/Nod protein family, confers responsiveness to bacterial
products and activates NF-κB, a transcription factor that plays a central role in innate
immunity. Recently, genetic variation in Nod2 has been associated with susceptibility to
Crohn's disease. Here, we report that expression of Nod2 is induced upon differentiation of
CD34+ hematopoietic progenitor cells into granulocyte or monocyte/macrophages. In
peripheral blood cells, the highest levels of Nod2 were observed in CD14+(monocytes) …
products and activates NF-κB, a transcription factor that plays a central role in innate
immunity. Recently, genetic variation in Nod2 has been associated with susceptibility to
Crohn's disease. Here, we report that expression of Nod2 is induced upon differentiation of
CD34+ hematopoietic progenitor cells into granulocyte or monocyte/macrophages. In
peripheral blood cells, the highest levels of Nod2 were observed in CD14+(monocytes) …