Cryptococcus neoformans Isolates from Transplant Recipients Are Not Selected for Resistance to Calcineurin Inhibitors by Current Immunosuppressive Regimens
JR Blankenship, N Singh, BD Alexander… - Journal of clinical …, 2005 - Am Soc Microbiol
JR Blankenship, N Singh, BD Alexander, J Heitman
Journal of clinical microbiology, 2005•Am Soc MicrobiolThe immunosuppressants tacrolimus (FK506) and cyclosporine A inhibit calcineurin and
have potent antifungal activity. In this study, 24% of Cryptococcus neoformans isolates from
solid-organ transplant patients exhibited altered sensitivity to these drugs, which may have
an impact on the infectious course but does not appear to be the consequence of
immunosuppressive therapy.
have potent antifungal activity. In this study, 24% of Cryptococcus neoformans isolates from
solid-organ transplant patients exhibited altered sensitivity to these drugs, which may have
an impact on the infectious course but does not appear to be the consequence of
immunosuppressive therapy.
Abstract
The immunosuppressants tacrolimus (FK506) and cyclosporine A inhibit calcineurin and have potent antifungal activity. In this study, 24% of Cryptococcus neoformans isolates from solid-organ transplant patients exhibited altered sensitivity to these drugs, which may have an impact on the infectious course but does not appear to be the consequence of immunosuppressive therapy.
American Society for Microbiology