Human papillomaviruses (HPVs) are the primary etiologic agents of cervical cancer. Thus,
cervical cancer and other HPV-associated malignancies might be prevented or treated by
HPV vaccines. Transmission of papillomavirus may be prevented by the generation of
antibodies to capsid proteins L1 and L2 that neutralize viral infection. However, because the
capsid proteins are not expressed at detectable levels by infected basal keratinocytes or in
HPV-transformed cells, therapeutic vaccines generally target nonstructural early viral …