CD4+ CD25+ T-Cell Production in Healthy Humans and in Patients with Thymic Hypoplasia
KE Sullivan, D McDonald-McGinn… - Clinical and Vaccine …, 2002 - Am Soc Microbiol
KE Sullivan, D McDonald-McGinn, EH Zackai
Clinical and Vaccine Immunology, 2002•Am Soc MicrobiolRegulatory T cells are found primarily in the CD4+ CD25+ fraction of T cells and play an
important role in the prevention of autoimmunity. We examined CD4+ CD25+ T cells in 33
healthy children and adults and compared them to a population with an inherited form of
thymic hypoplasia and a predisposition to autoimmune disease. Absolute numbers of CD4+
CD25+ T cells were markedly higher in healthy infants than in infants with chromosome
22q11. 2 deletion syndrome.
important role in the prevention of autoimmunity. We examined CD4+ CD25+ T cells in 33
healthy children and adults and compared them to a population with an inherited form of
thymic hypoplasia and a predisposition to autoimmune disease. Absolute numbers of CD4+
CD25+ T cells were markedly higher in healthy infants than in infants with chromosome
22q11. 2 deletion syndrome.
Abstract
Regulatory T cells are found primarily in the CD4+ CD25+ fraction of T cells and play an important role in the prevention of autoimmunity. We examined CD4+ CD25+ T cells in 33 healthy children and adults and compared them to a population with an inherited form of thymic hypoplasia and a predisposition to autoimmune disease. Absolute numbers of CD4+ CD25+ T cells were markedly higher in healthy infants than in infants with chromosome 22q11.2 deletion syndrome.
American Society for Microbiology