[HTML][HTML] Altered adrenal gland cholesterol metabolism in the apoE-deficient mouse
FE Thorngate, PA Strockbine, SK Erickson… - Journal of Lipid …, 2002 - ASBMB
Previous studies suggest the hypothesis that apoE produced by adrenocortical cells
modulates cellular cholesterol metabolism to enhance the storage of esterified cholesterol
(4444411) at the expense of cholesterol delivery to the steroidogenic pathway. In the
present study, parameters of adrenal cholesterol metabolism and corticosteroid production
were examined in wild type and apoE-deficient (apoe−/−) mice. Adrenal gland EC content
and the EC/free cholesterol (FC) ratio in mice stressed by adrenocorticotropin (ACTH) …
modulates cellular cholesterol metabolism to enhance the storage of esterified cholesterol
(4444411) at the expense of cholesterol delivery to the steroidogenic pathway. In the
present study, parameters of adrenal cholesterol metabolism and corticosteroid production
were examined in wild type and apoE-deficient (apoe−/−) mice. Adrenal gland EC content
and the EC/free cholesterol (FC) ratio in mice stressed by adrenocorticotropin (ACTH) …