IL-21: a novel IL-2–family lymphokine that modulates B, T, and natural killer cell responses
T Habib, A Nelson, K Kaushansky - Journal of Allergy and Clinical …, 2003 - Elsevier
IL-21 is a recently described type I cytokine produced by activated CD4+ T cells that
profoundly affects the growth, survival, and functional activation of B, T, and natural killer
lymphocytes in concert with other cytokines or activating stimuli. Structurally, IL-21 is
predicted to display a 4-helix–bundle–type fold with significant homology to IL-2, IL-4, and IL-
15 and mediates its biologic effects through a novel type I cytokine receptor, IL-21R, in
conjunction with the common cytokine receptor γ chain (γc) of the IL-2, IL-4, IL-7, IL-9, and IL …
profoundly affects the growth, survival, and functional activation of B, T, and natural killer
lymphocytes in concert with other cytokines or activating stimuli. Structurally, IL-21 is
predicted to display a 4-helix–bundle–type fold with significant homology to IL-2, IL-4, and IL-
15 and mediates its biologic effects through a novel type I cytokine receptor, IL-21R, in
conjunction with the common cytokine receptor γ chain (γc) of the IL-2, IL-4, IL-7, IL-9, and IL …