HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins
AM Verhagen, J Silke, PG Ekert, M Pakusch… - Journal of Biological …, 2002 - ASBMB
Inhibitor of apoptosis (IAP) proteins inhibit caspases, a function counteracted by IAP
antagonists, insect Grim, HID, and Reaper and mammalian DIABLO/Smac. We now
demonstrate that HtrA2, a mammalian homologue of the Escherichia coli heat shock-
inducible protein HtrA, can bind to MIHA/XIAP, MIHB, and baculoviral OpIAP but not survivin.
Although produced as a 50-kDa protein, HtrA2 is processed to yield an active serine
protease with an N terminus similar to that of Grim, Reaper, HID, and DIABLO/Smac that …
antagonists, insect Grim, HID, and Reaper and mammalian DIABLO/Smac. We now
demonstrate that HtrA2, a mammalian homologue of the Escherichia coli heat shock-
inducible protein HtrA, can bind to MIHA/XIAP, MIHB, and baculoviral OpIAP but not survivin.
Although produced as a 50-kDa protein, HtrA2 is processed to yield an active serine
protease with an N terminus similar to that of Grim, Reaper, HID, and DIABLO/Smac that …
