[HTML][HTML] Distinct ligand-dependent roles for p38 MAPK in priming and activation of the neutrophil NADPH oxidase
GE Brown, MQ Stewart, SA Bissonnette… - Journal of Biological …, 2004 - ASBMB
In response to certain cytokines and inflammatory mediators, the activity of the neutrophil
NADPH oxidase enzyme is primed for enhanced superoxide production when the cells
receive a subsequent oxidase-activating stimulus. The relative role of p38 MAPK in the
priming and activation processes is incompletely understood. We have developed a 2-step
assay that allows the relative contributions of p38 MAPK activity in priming to be
distinguished from those involved in oxidase activation. Using this assay, together with in …
NADPH oxidase enzyme is primed for enhanced superoxide production when the cells
receive a subsequent oxidase-activating stimulus. The relative role of p38 MAPK in the
priming and activation processes is incompletely understood. We have developed a 2-step
assay that allows the relative contributions of p38 MAPK activity in priming to be
distinguished from those involved in oxidase activation. Using this assay, together with in …