[HTML][HTML] Sialic acid recognition by Vibrio cholerae neuraminidase

I Moustafa, H Connaris, M Taylor, V Zaitsev… - Journal of Biological …, 2004 - ASBMB
Vibrio cholerae neuraminidase (VCNA) plays a significant role in the pathogenesis of
cholera by removing sialic acid from higher order gangliosides to unmask GM1, the receptor
for cholera toxin. We previously showed that the structure of VCNA is composed of a central
β-propeller catalytic domain flanked by two lectin-like domains; however the nature of the
carbohydrates recognized by these lectin domains has remained unknown. We present here
structures of the enzyme in complex with two substrates, α-2, 3-sialyllactose and α-2, 6 …