Killing the messenger: short RNAs that silence gene expression
DM Dykxhoorn, CD Novina, PA Sharp - Nature reviews Molecular cell …, 2003 - nature.com
DM Dykxhoorn, CD Novina, PA Sharp
Nature reviews Molecular cell biology, 2003•nature.comShort interfering RNAs can be used to silence gene expression in a sequence-specific
manner in a process that is known as RNA interference. The application of RNA interference
in mammals has the potential to allow the systematic analysis of gene expression and holds
the possibility of therapeutic gene silencing. Much of the promise of RNA interference will
depend on the recent advances in short-RNA-based silencing technologies.
manner in a process that is known as RNA interference. The application of RNA interference
in mammals has the potential to allow the systematic analysis of gene expression and holds
the possibility of therapeutic gene silencing. Much of the promise of RNA interference will
depend on the recent advances in short-RNA-based silencing technologies.
Abstract
Short interfering RNAs can be used to silence gene expression in a sequence-specific manner in a process that is known as RNA interference. The application of RNA interference in mammals has the potential to allow the systematic analysis of gene expression and holds the possibility of therapeutic gene silencing. Much of the promise of RNA interference will depend on the recent advances in short-RNA-based silencing technologies.
nature.com