[HTML][HTML] The Soluble Exoplasmic Domain of the Type II Transforming Growth Factor (TGF)-β Receptor: A HETEROGENEOUSLY GLYCOSYLATED PROTEIN WITH …
The transforming growth factor (TGF)-β type II receptor is a transmembrane serine/threonine
kinase which is essential for all TGF-β-induced signals. In several cell types TGF-β2 is as
potent as TGF-β1 or TGF-β3 in inducing cellular responses, yet TGF-β2 does not bind to the
majority of expressed type II receptors. Here we characterized the properties of the soluble
extracellular domain of the human TGF-β type II receptor synthesized in COS-7 cells. Like
the membrane-attached type II receptor, the soluble receptor contains complex N-linked …
kinase which is essential for all TGF-β-induced signals. In several cell types TGF-β2 is as
potent as TGF-β1 or TGF-β3 in inducing cellular responses, yet TGF-β2 does not bind to the
majority of expressed type II receptors. Here we characterized the properties of the soluble
extracellular domain of the human TGF-β type II receptor synthesized in COS-7 cells. Like
the membrane-attached type II receptor, the soluble receptor contains complex N-linked …
