[HTML][HTML] The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription
DI Zhang, AJ Paley, G Childs - Journal of Biological Chemistry, 1998 - ASBMB
The ZFM1 protein is both a transcriptional repressor and identical to the splicing factor SF1.
ZFM1 was shown to interact with and repress transcription from the glycine, glutamine,
serine, and threonine-rich transcription activation domain of the sea urchin transcription
factor, stage-specific activator protein (SSAP). EWS, a human protein involved in cellular
transformation in Ewing's sarcoma tumors, contains an NH 2-terminal transcriptional
activation domain (NTD) which resembles that of SSAP in both amino acid composition and …
ZFM1 was shown to interact with and repress transcription from the glycine, glutamine,
serine, and threonine-rich transcription activation domain of the sea urchin transcription
factor, stage-specific activator protein (SSAP). EWS, a human protein involved in cellular
transformation in Ewing's sarcoma tumors, contains an NH 2-terminal transcriptional
activation domain (NTD) which resembles that of SSAP in both amino acid composition and …