[HTML][HTML] Overexpression of diacylglycerol acyltransferase-1 reduces phospholipid synthesis, proliferation, and invasiveness in simian virus 40-transformed human …
C Bagnato, RA Igal - Journal of Biological Chemistry, 2003 - ASBMB
Diacylglycerol (DAG) is a versatile molecule that participates as substrate in the synthesis of
structural and energetic lipids, and acts as the physiological signal that activates protein
kinase C. Diacylglycerol acyltransferase (DGAT), the last committed enzyme in
triacylglycerol synthesis, could potentially regulate the content and use of both signaling and
glycerolipid substrate DAG by converting it into triacylglycerol. To test this hypothesis, we
stably overexpressed the DGAT1 mouse gene in human lung SV40-transformed fibroblasts …
structural and energetic lipids, and acts as the physiological signal that activates protein
kinase C. Diacylglycerol acyltransferase (DGAT), the last committed enzyme in
triacylglycerol synthesis, could potentially regulate the content and use of both signaling and
glycerolipid substrate DAG by converting it into triacylglycerol. To test this hypothesis, we
stably overexpressed the DGAT1 mouse gene in human lung SV40-transformed fibroblasts …
