[HTML][HTML] Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high …
Adiponectin is a multifunctional adipokine that circulates as several oligomeric complexes in
the blood stream. However, the molecular basis that regulates the production of the
adiponectin oligomers remains largely elusive. We have shown previously that several
conserved lysine residues (positions 68, 71, 80, and 104) within the collagenous domain of
adiponectin are modified by hydroxylation and glycosylation (Wang, Y., Xu, A., Knight, C.,
Xu, LY, and Cooper, GJ (2002) J. Biol. Chem. 277, 19521–19529). Here, we investigated the …
the blood stream. However, the molecular basis that regulates the production of the
adiponectin oligomers remains largely elusive. We have shown previously that several
conserved lysine residues (positions 68, 71, 80, and 104) within the collagenous domain of
adiponectin are modified by hydroxylation and glycosylation (Wang, Y., Xu, A., Knight, C.,
Xu, LY, and Cooper, GJ (2002) J. Biol. Chem. 277, 19521–19529). Here, we investigated the …