[HTML][HTML] Androgen receptor gene knockout male mice exhibit impaired cardiac growth and exacerbation of angiotensin II-induced cardiac fibrosis
Y Ikeda, K Aihara, T Sato, M Akaike… - Journal of Biological …, 2005 - ASBMB
Androgen has anabolic effects on cardiac myocytes and has been shown to enhance left
ventricular enlargement and function. However, the physiological and patho-physiological
roles of androgen in cardiac growth and cardiac stress-induced remodeling remains
unclear. We aimed to clarify whether the androgen-nuclear androgen receptor (AR) system
contributes to the cardiac growth and angiotensin II (Ang II)-stimulated cardiac remodeling
by using systemic AR-null male mice. AR knock-out (ARKO) male mice, at 25 weeks of age …
ventricular enlargement and function. However, the physiological and patho-physiological
roles of androgen in cardiac growth and cardiac stress-induced remodeling remains
unclear. We aimed to clarify whether the androgen-nuclear androgen receptor (AR) system
contributes to the cardiac growth and angiotensin II (Ang II)-stimulated cardiac remodeling
by using systemic AR-null male mice. AR knock-out (ARKO) male mice, at 25 weeks of age …
