MUC1 initiates a calcium signal after ligation by intercellular adhesion molecule-1
JJ Rahn, Q Shen, BK Mah, JC Hugh - Journal of Biological Chemistry, 2004 - ASBMB
The MUC1 mucin is normally restricted to the apical surface of breast epithelial cells. In
tumors, it is frequently overexpressed and underglycosylated. The MUC1 peptide core
mediates firm adhesion of tumor cells to adjacent cells via binding to intercellular adhesion
molecule-1 (ICAM-1). There is increasing evidence that MUC1 is involved in signaling, with
current reports focusing on phosphorylation of the MUC1 cytoplasmic tail after indirect or
artificial modes of stimulation. ICAM-1 is the only known direct ligand of the MUC1 …
tumors, it is frequently overexpressed and underglycosylated. The MUC1 peptide core
mediates firm adhesion of tumor cells to adjacent cells via binding to intercellular adhesion
molecule-1 (ICAM-1). There is increasing evidence that MUC1 is involved in signaling, with
current reports focusing on phosphorylation of the MUC1 cytoplasmic tail after indirect or
artificial modes of stimulation. ICAM-1 is the only known direct ligand of the MUC1 …