[HTML][HTML] Transcriptional regulation of apolipoprotein AI gene expression by the nuclear receptor RORα
N Vu-Dac, P Gervois, T Grötzinger, P De Vos… - Journal of Biological …, 1997 - ASBMB
Since elevated concentrations of plasma high density lipoprotein (HDL) and its major
apolipoprotein (apo), apoA-I, confer protection against atherosclerosis, considerable
research efforts have focussed on the identification of factors regulating apoA-I gene
expression in an attempt to increase its production. Nuclear receptors are interesting
candidates because they are transcription factors whose activity is ligand-dependent. In the
present study we identified the orphan receptor RORα1 as an activator of apoA-I gene …
apolipoprotein (apo), apoA-I, confer protection against atherosclerosis, considerable
research efforts have focussed on the identification of factors regulating apoA-I gene
expression in an attempt to increase its production. Nuclear receptors are interesting
candidates because they are transcription factors whose activity is ligand-dependent. In the
present study we identified the orphan receptor RORα1 as an activator of apoA-I gene …