The aim of this study was to determine, if gemfibrozil has anti-atherogenic actions on human
vascular smooth muscle cells (SMCs) and whether these actions are affected by high
glucose concentrations, which mimic the hyperglycemia of diabetes. Proliferation of SMCs
treated with gemfibrozil was estimated by cell counting (Coulter Counter) and [3H] thymidine
incorporation, migration in a scrape-wound assay, proteoglycan (PG) biosynthesis and
glycosaminoglycan (GAG) synthesis on xyloside by [35S] sulfate labeling and sizing by …