Junctional sequences of T cell receptor γδ genes: implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining
JJ Lafaille, A DeCloux, M Bonneville, Y Takagaki… - Cell, 1989 - cell.com
JJ Lafaille, A DeCloux, M Bonneville, Y Takagaki, S Tonegawa
Cell, 1989•cell.comNucleotide sequences of a large number of V-(D) J junctions of T cell receptor (TCR) y and 6
genes show that most fetal thymocytes express on their surface one of just two yS TCRs
known to be expressed by epidermal y6 T cells (s-IEL) or intraepithelial yS T cells
associated with female reproductive organs (r-IEL). In Contras& yS TCRs expressed on
adult thymocytes are highly diverse as a result of multiple combinations of gene segments
as well as junctional deletions and insertions, indicating that developmental time-and cell …
genes show that most fetal thymocytes express on their surface one of just two yS TCRs
known to be expressed by epidermal y6 T cells (s-IEL) or intraepithelial yS T cells
associated with female reproductive organs (r-IEL). In Contras& yS TCRs expressed on
adult thymocytes are highly diverse as a result of multiple combinations of gene segments
as well as junctional deletions and insertions, indicating that developmental time-and cell …
Summary
Nucleotide sequences of a large number of V-(D) J junctions of T cell receptor (TCR) y and 6 genes show that most fetal thymocytes express on their surface one of just two yS TCRs known to be expressed by epidermal y6 T cells (s-IEL) or intraepithelial yS T cells associated with female reproductive organs (r-IEL). In Contras& yS TCRs expressed on adult thymocytes are highly diverse as a result of multiple combinations of gene segments as well as junctional deletions and insertions, indicating that developmental time-and cell lineage-dependent mechanisms exist that control the extent of $5 TCR diversity. In addition, this study revealed a new type of junctional insertion (P nucleotides), which led to a new model of V-(D)-J joining generally applicable to immunoglobulin and TCR genes.
cell.com