Advances in the hereditary spastic paraplegias
JK Fink - Experimental neurology, 2003 - Elsevier
JK Fink
Experimental neurology, 2003•ElsevierThis review summarizes advances in understanding the genetics of the hereditary spastic
paraplegias (HSPs), a diverse group of inherited disorders in which the primary symptom is
insidiously progressive difficulty walking due to lower extremity spastic weakness. Twenty
HSP loci and nine HSP genes have been discovered. This progress has yielded new
insights into the diverse molecular pathogenesis that underlies these clinically similar
disorders.
paraplegias (HSPs), a diverse group of inherited disorders in which the primary symptom is
insidiously progressive difficulty walking due to lower extremity spastic weakness. Twenty
HSP loci and nine HSP genes have been discovered. This progress has yielded new
insights into the diverse molecular pathogenesis that underlies these clinically similar
disorders.
This review summarizes advances in understanding the genetics of the hereditary spastic paraplegias (HSPs), a diverse group of inherited disorders in which the primary symptom is insidiously progressive difficulty walking due to lower extremity spastic weakness. Twenty HSP loci and nine HSP genes have been discovered. This progress has yielded new insights into the diverse molecular pathogenesis that underlies these clinically similar disorders.
Elsevier