[HTML][HTML] Death signal-induced localization of p53 protein to mitochondria: a potential role in apoptotic signaling
ND Marchenko, A Zaika, UM Moll - Journal of Biological Chemistry, 2000 - ASBMB
The mechanism of p53-mediated apoptosis after cellular stress remains poorly understood.
Evidence suggests that p53 induces cell death by a multitude of molecular pathways
involving activation of target genes and transcriptionally independent direct signaling.
Mitochondria play a key role in apoptosis. We show here that a fraction of p53 protein
localizes to mitochondria at the onset of p53-dependent apoptosis but not during p53-
independent apoptosis or p53-mediated cell cycle arrest. The accumulation of p53 to …
Evidence suggests that p53 induces cell death by a multitude of molecular pathways
involving activation of target genes and transcriptionally independent direct signaling.
Mitochondria play a key role in apoptosis. We show here that a fraction of p53 protein
localizes to mitochondria at the onset of p53-dependent apoptosis but not during p53-
independent apoptosis or p53-mediated cell cycle arrest. The accumulation of p53 to …