[HTML][HTML] Alzheimer's disease amyloid-β binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase …
CC Curtain, F Ali, I Volitakis, RA Cherny… - Journal of Biological …, 2001 - ASBMB
Amyloid β peptide (Aβ) is the major constituent of extracellular plaques and perivascular
amyloid deposits, the pathognomonic neuropathological lesions of Alzheimer's disease. Cu
2+ and Zn 2+ bind Aβ, inducing aggregation and giving rise to reactive oxygen species.
These reactions may play a deleterious role in the disease state, because high
concentrations of iron, copper, and zinc have been located in amyloid in diseased brains.
Here we show that coordination of metal ions to Aβ is the same in both aqueous solution …
amyloid deposits, the pathognomonic neuropathological lesions of Alzheimer's disease. Cu
2+ and Zn 2+ bind Aβ, inducing aggregation and giving rise to reactive oxygen species.
These reactions may play a deleterious role in the disease state, because high
concentrations of iron, copper, and zinc have been located in amyloid in diseased brains.
Here we show that coordination of metal ions to Aβ is the same in both aqueous solution …