Signaling pathways activated by vasoactive peptides in the cardiac myocyte and their role in myocardial pathologies
PH Sugden - Journal of cardiac failure, 2002 - Elsevier
In addition to its vasoactive effects, endothelin-1 (ET-1) causes hypertrophy of isolated
cardiac myocytes. Since the early 1990s, the cell signaling events initiated by the binding of
ET-1 to its cell surface receptors on the myocyte, and their roles in myocyte hypertrophy
have been a particular interest of mine. ET-1 activates several intracellular signaling
pathways in cardiac myocytes, notably the protein kinase C pathway and the mitogen-
activated protein kinase cascades. It is likely that activation of these pathways contributes to …
cardiac myocytes. Since the early 1990s, the cell signaling events initiated by the binding of
ET-1 to its cell surface receptors on the myocyte, and their roles in myocyte hypertrophy
have been a particular interest of mine. ET-1 activates several intracellular signaling
pathways in cardiac myocytes, notably the protein kinase C pathway and the mitogen-
activated protein kinase cascades. It is likely that activation of these pathways contributes to …
