Effect of amino acids and proteins on insulin secretion in man
SS Fajans, JC Floyd Jr, RF Knopf, JW Conn - … , Berlin, May 26 to 27, 1967, 1969 - Elsevier
Following the demonstration that administration of leucine accentuates the hypoglycemia of
some patients with “idiopathic hypoglycaemia of childhood”(1956) and of some patients with
pancreatic islet cell tumours (1959) we initiated studies to explore the mechanism of leucine-
induced hypoglycaemia. Sensitivity to leucine-hypoglycaemia can be induced consistently
in healthy subjects after administration of sulfonylurea compounds. Increased release of
pancreatic insulin is the primary mechanism by which leucine causes a fall in blood glucose …
some patients with “idiopathic hypoglycaemia of childhood”(1956) and of some patients with
pancreatic islet cell tumours (1959) we initiated studies to explore the mechanism of leucine-
induced hypoglycaemia. Sensitivity to leucine-hypoglycaemia can be induced consistently
in healthy subjects after administration of sulfonylurea compounds. Increased release of
pancreatic insulin is the primary mechanism by which leucine causes a fall in blood glucose …
