[HTML][HTML] Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine …
AP Halestrap, KY Woodfield, CP Connern - Journal of Biological Chemistry, 1997 - ASBMB
Stimulation of the mitochondrial permeability transition (MPT) in de-energized mitochondria
by phenylarsine oxide (PheArs) is greater than that by diamide and t-butylhydroperoxide
(TBH), yet the increase in CyP binding to the inner mitochondrial membrane (Connern, CP
and Halestrap, AP (1994) Biochem. J. 302, 321-324) is less. From a range of nucleotides
tested only ADP, deoxy-ADP, and ATP inhibited the MPT. ADP inhibition involved two sites
with K i values of about 1 and 25 μM which were independent of [Ca 2+] and CyP binding …
by phenylarsine oxide (PheArs) is greater than that by diamide and t-butylhydroperoxide
(TBH), yet the increase in CyP binding to the inner mitochondrial membrane (Connern, CP
and Halestrap, AP (1994) Biochem. J. 302, 321-324) is less. From a range of nucleotides
tested only ADP, deoxy-ADP, and ATP inhibited the MPT. ADP inhibition involved two sites
with K i values of about 1 and 25 μM which were independent of [Ca 2+] and CyP binding …