[HTML][HTML] Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule
Claudins, most of which end in valine at their COOH termini, constitute tight junction (TJ)
strands, suggesting that TJ strands strongly attract PDZ-containing proteins. Indeed, ZO-1,-2,
and-3, each of which contains three PDZ domains, were shown to directly bind to claudins.
Using the yeast two-hybrid system, we identified ZO-1 and MUPP1 (multi-PDZ domain
protein 1) as binding partners for the COOH terminus of claudin-1. MUPP1 has been
identified as a protein that contains 13 PDZ domains, but it has not been well characterized …
strands, suggesting that TJ strands strongly attract PDZ-containing proteins. Indeed, ZO-1,-2,
and-3, each of which contains three PDZ domains, were shown to directly bind to claudins.
Using the yeast two-hybrid system, we identified ZO-1 and MUPP1 (multi-PDZ domain
protein 1) as binding partners for the COOH terminus of claudin-1. MUPP1 has been
identified as a protein that contains 13 PDZ domains, but it has not been well characterized …