The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression
A Lymboussaki, E Pignatti, G Montosi, C Garuti… - Journal of …, 2003 - Elsevier
Background/Aims: MTP1/Ferroportin1/IREG1, the product of the SLC40A1 gene, is a main
iron export protein in mammals. However, the way this gene is regulated by iron is still
unclear. The aim of this study was to investigate the functional role of genomic SLC40A1
elements in response to iron. Methods: Vectors containing either∽ 2.6 kb 5′ flanking
region or deletion constructs, including one devoid of an iron responsive element (SLC40A1-
ΔIRE-Luc), were analyzed by luciferase reporter gene in transfected HepG2, CaCO2 and …
iron export protein in mammals. However, the way this gene is regulated by iron is still
unclear. The aim of this study was to investigate the functional role of genomic SLC40A1
elements in response to iron. Methods: Vectors containing either∽ 2.6 kb 5′ flanking
region or deletion constructs, including one devoid of an iron responsive element (SLC40A1-
ΔIRE-Luc), were analyzed by luciferase reporter gene in transfected HepG2, CaCO2 and …
