The immunoglobulin G heavy chain repertoire in multiple sclerosis plaques is distinct from the heavy chain repertoire in peripheral blood lymphocytes
GP Owens, MP Burgoon, J Anthony… - Clinical …, 2001 - Elsevier
Analyses have shown that the repertoire of Ig heavy chain sequences (VH) expressed in
multiple sclerosis (MS) plaques or cerebrospinal fluid is consistent with B cell clonal
expansion and affinity maturation. PCR amplification of VH sequences from MS lesions
obtained from an acute MS patient at autopsy revealed oligoclonal and extensively mutated
VH sequences from plaque–periplaque regions with discrete intraclonal differences
indicative of B cell clonal expansion in the groups of overrepresented major sequences …
multiple sclerosis (MS) plaques or cerebrospinal fluid is consistent with B cell clonal
expansion and affinity maturation. PCR amplification of VH sequences from MS lesions
obtained from an acute MS patient at autopsy revealed oligoclonal and extensively mutated
VH sequences from plaque–periplaque regions with discrete intraclonal differences
indicative of B cell clonal expansion in the groups of overrepresented major sequences …