[HTML][HTML] The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility
DM Selva, V Hirsch-Reinshagen, B Burgess… - Journal of Lipid …, 2004 - ASBMB
The liver X receptor/retinoid X receptor (LXR/RXR)-regulated gene ABCA1 effluxes cellular
cholesterol and phospholipid to apolipoprotein A1 (apoA1), which is the rate-limiting step in
high-density lipoprotein synthesis. The RXR pathway plays a critical role in testicular lipid
trafficking, and RXRβ-deficient male mice are sterile and accumulate lipids in Sertoli cells.
Here, we demonstrate that ABCA1 mRNA and protein are abundant in Sertoli cells, whereas
germ cells express little ABCA1. LXR/RXR agonists stimulate ABCA1 expression in cultured …
cholesterol and phospholipid to apolipoprotein A1 (apoA1), which is the rate-limiting step in
high-density lipoprotein synthesis. The RXR pathway plays a critical role in testicular lipid
trafficking, and RXRβ-deficient male mice are sterile and accumulate lipids in Sertoli cells.
Here, we demonstrate that ABCA1 mRNA and protein are abundant in Sertoli cells, whereas
germ cells express little ABCA1. LXR/RXR agonists stimulate ABCA1 expression in cultured …