Antibodies directed to the Pseudomonas aeruginosa lipopolysaccharide (LPS) O-antigens
have clearly shown to mediate the most effective immunity to infection caused by LPS-
smooth strains. Such strains are major causes of disease in immunocompromised hosts
such as burn or cancer patients, individuals in intensive care units, and those who utilize
extended-wear contact lenses. Yet producing an effective vaccine composed of non-toxic,
immunogenic polysaccharides has been challenging. The chemical diversity among the …