The molecular genetics of recurring chromosome abnormalities in acute myeloid leukemia
Y Hayashi - Seminars in hematology, 2000 - Elsevier
Chromosome translocations are closely associated with a particular morphologic or
phenotypic subtype of acute myeloid leukemia (AML). Cloning the genes at the breakpoints
of these rearrangements has had a major impact on our understanding of the molecular
biology of AML. Thus, cytogenetic or direct molecular genetic methods have become an
essential part of the routine diagnostic evaluation and follow-up of AML patients. This review
describes the MLL gene on 11q23 including three types of t (10; 11), the TLS/FUS gene on …
phenotypic subtype of acute myeloid leukemia (AML). Cloning the genes at the breakpoints
of these rearrangements has had a major impact on our understanding of the molecular
biology of AML. Thus, cytogenetic or direct molecular genetic methods have become an
essential part of the routine diagnostic evaluation and follow-up of AML patients. This review
describes the MLL gene on 11q23 including three types of t (10; 11), the TLS/FUS gene on …