[HTML][HTML] Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration
T Wuestefeld, C Klein, KL Streetz, U Betz… - Journal of Biological …, 2003 - ASBMB
After tissue loss the liver has the unique capacity to restore its mass by hepatocyte
proliferation. Interleukin-6 (IL6)-deficient mice show a lack in DNA synthesis after partial
hepatectomy (PH). To define better the role of IL6 and its family members for liver
regeneration after PH, we used conditional knockout mice for glycoprotein 130 (gp130), the
common signal transducer of all IL6 family members. We show that gp130-dependent
pathways control Stat3 activation after PH. By using gene array analysis, we demonstrate …
proliferation. Interleukin-6 (IL6)-deficient mice show a lack in DNA synthesis after partial
hepatectomy (PH). To define better the role of IL6 and its family members for liver
regeneration after PH, we used conditional knockout mice for glycoprotein 130 (gp130), the
common signal transducer of all IL6 family members. We show that gp130-dependent
pathways control Stat3 activation after PH. By using gene array analysis, we demonstrate …