[HTML][HTML] Translocation of Bim to the endoplasmic reticulum (ER) mediates ER stress signaling for activation of caspase-12 during ER stress-induced apoptosis
N Morishima, K Nakanishi, K Tsuchiya… - Journal of Biological …, 2004 - ASBMB
Endoplasmic reticulum (ER) stress activates caspase-12 in murine cells, triggering the ER
stress-specific cascade for implementation of apoptosis. In C2C12 murine myoblast cells,
activation of the cascade occurs without release of cytochrome c from mitochondria,
suggesting that the cascade is independent of mitochondrial damage. Stable
overexpression of Bcl-xL in C2C12 cells suppressed activation of caspase-12 and
apoptosis. In ER-stressed cells, but not in normal cells, Bcl-xL was co-immunoprecipitated …
stress-specific cascade for implementation of apoptosis. In C2C12 murine myoblast cells,
activation of the cascade occurs without release of cytochrome c from mitochondria,
suggesting that the cascade is independent of mitochondrial damage. Stable
overexpression of Bcl-xL in C2C12 cells suppressed activation of caspase-12 and
apoptosis. In ER-stressed cells, but not in normal cells, Bcl-xL was co-immunoprecipitated …