S-Nitrosylated proteins form when a cysteine thiol reacts with nitric oxide (NO) in the
presence of an electron acceptor to form an S-NO bond. Under physiological conditions, this
posttranslational modification affects the function a wide array of cell proteins, ranging from
ion channels to nuclear regulatory proteins. Recent evidence suggests that 1) S-nitrosylated
proteins can be synthesized by exposure of specific redox-active motifs to NO, through
transnitrosation/transfer reactions, or through metalloprotein-catalyzed reactions; 2) S …