[HTML][HTML] Hydrogen peroxide activates the Gas6-Axl pathway in vascular smooth muscle cells
A Konishi, T Aizawa, A Mohan, VA Korshunov… - Journal of Biological …, 2004 - ASBMB
Axl, a receptor tyrosine kinase, is involved in cell survival, proliferation, and migration. We
have shown that Axl expression increases in the neointima of balloon-injured rat carotids.
Because oxidative stress is known to play a major role in remodeling of injured vessels, we
hypothesized that H 2 O 2 might activate Axl by promoting autophosphorylation. H 2 O 2
rapidly stimulated Axl tyrosine phosphorylation in rat vascular smooth muscle cells within 1
min that was maximal at 5 min (6-fold). The response to H 2 O 2 was concentration …
have shown that Axl expression increases in the neointima of balloon-injured rat carotids.
Because oxidative stress is known to play a major role in remodeling of injured vessels, we
hypothesized that H 2 O 2 might activate Axl by promoting autophosphorylation. H 2 O 2
rapidly stimulated Axl tyrosine phosphorylation in rat vascular smooth muscle cells within 1
min that was maximal at 5 min (6-fold). The response to H 2 O 2 was concentration …